人胃癌淋巴管密度和面积及其与淋巴结转移的关系

目的研究人胃癌淋巴管的密度和面积及其与淋巴结转移的关系。方法采用D2-40淋巴管内皮标记性抗体免疫组织化学染色方法,检测70例人胃癌中心区、癌旁区、正常区内的淋巴管,分析淋巴管的形态学特征与淋巴结转移及其他临床病理因素之间的关系。结果人胃癌癌旁区淋巴管密度高于正常区,平均面积、平均周径及总面积小于正常区,差异均有统计学意义。淋巴结转移组人胃癌癌旁区淋巴管密度及平均面积、平均周径均高于无淋巴结转移组。结论人胃癌淋巴管新生存在于胃癌癌旁区,新生淋巴管管腔小,不足以形成良好的淋巴回流;人胃癌癌旁区淋巴管密度、平均面积与淋巴结转移有关,有望成为预测淋巴结转移及决定手术方式的重要因素。

DENSITY AND AREA OF LYMPH VESSELS IN HUMAN GASTRIC CANCER AND ITS RELATIONSHIP WITH LYMPH NODE METASTASIS

Objective To study the morphological characteristics of lymph vessels in human gastric cancer and to investigate whether lymph vessel density(LVD) and lymph vessel area are related with lymph node metastasis(LM). Methods Lymphatics in the normal,peripheral and central regions of 70 samples of primary human gastric cancer were investigated by immunohistochemical staining for D2-40.The relation between morphological characteristics of lymph vessel and LM and other established clinicopathological parameters were analyzed. Results Compared with the normal region of human gastric cancer,the peripheral region was found with a significantly highly LVD,and with significant decreases in the average area,average perimeter and total area of lymphatics.The LVD,average area and average perimeter of lymphatics in the peripheral region of human gastric cancer with LM significantly increased compared with those of human gastric cancer without LM.Conclusion Lymph angiogenesis exists in the peripheral region of human gastric cancer,and the lumina of newly formed lymphatics is small,therefore the lymphocinesia of that region is inadequate.Increased LVD and lymph vessel area were significantly related with LM,and may play an important role in detecting LM in human gastric cancer and the decision making for additional surgery.