Hydrogen sulfide protects against amyloid beta-peptide induced neuronal injury via attenuating inflammatory responses in a rat model |
| |
Authors: | Hao Fan Yu Guo Xiaoyan Liang Yibiao Yuan Xiaohong Qi Min Wang Jianhua Ma Hong Zhou |
| |
Affiliation: | 1.Laboratory Center for Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu 210029, China2.Department of Pathophysiology, Nanjing Medical University, Nanjing, Jiangsu 210029, China3.Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, China |
| |
Abstract: | Neuroinflammation has been recognized to play a critical role in the pathogenesis of Alzheimer''s disease (AD), which is pathologically characterized by the accumulation of senile plaques containing activated microglia and amyloid β-peptides (Aβ). In the present study, we examined the neuroprotective effects of hydrogen sulfide (H2S) on neuroinflammation in rats with Aβ1-40 hippocampal injection. We found that Aβ-induced rats exhibited a disorder of pyramidal cell layer arrangement, and a decrease of mean pyramidal cell number in the CA1 hippocampal region compared with those in sham operated rats. NaHS (a donor of H2S, 5.6 mg/kg/d, i.p.) treatment for 3 weeks rescued neuronal cell death significantly. Moreover, we found that H2S dramatically suppressed the release of TNF-α, IL-1β and IL-6 in the hippocampus. Consistently, both immunohistochemistry and Western blotting assays showed that H2S inhibited the upregulation of COX-2 and the activation of NF-κB in the hippocampus. In conclusion, our data indicate that H2S suppresses neuroinflammation via inhibition of the NF-κB activation pathway in the Aβ-induced rat model and has potential value for AD therapy. |
| |
Keywords: | Alzheimer''s disease, hydrogen sulfide, cyclooxygenase-2, nuclear factor-κ B (NF-κ B), amyloid |
|
| 点击此处可从《生物医学研究杂志》浏览原始摘要信息 |
|
点击此处可从《生物医学研究杂志》下载全文 |
|