Pharmacokinetics of Caspofungin in Critically Ill Patients on Continuous Renal Replacement Therapy |
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| Authors: | Stefan Weiler Christoph Seger Hartwig Pfisterer Eva Stienecke Florian Stippler René Welte Michael Joannidis Andrea Griesmacher Romuald Bellmann |
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| Affiliation: | Clinical Pharmacokinetics Unit, Inflammation Research Laboratory, Department of Internal Medicine, Innsbruck Medical Universitya;Central Institute for Medical and Chemical Laboratory Diagnostics, Innsbruck General Hospitalb;Medical Intensive Care and Emergency Unit, Department of Internal Medicine, Innsbruck Medical University,c Innsbruck, Austria |
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| Abstract: | Caspofungin pharmacokinetics was assessed in 27 critically ill patients, including 7 on continuous venovenous hemofiltration (CVVH), 8 on continuous venovenous hemodialysis (CVVHD), and 13 not requiring continuous renal replacement therapy (CRRT). Caspofungin exposure during CRRT was very similar to that of the control group and comparable to that in healthy volunteers. Caspofungin clearance by CRRT was very low. Therefore, the standard dosage of caspofungin is probably adequate for critically ill patients undergoing CVVH or CVVHD. |
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