A prospective investigation of fish,meat and cooking-related carcinogens with endometrial cancer incidence |
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| Authors: | H Arem M J Gunter A J Cross A R Hollenbeck R Sinha |
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| Institution: | 1.Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA;2.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK;3.AARP, Washington, DC, USA |
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| Abstract: | Background: There are limited prospective studies of fish and meat intakes with risk of endometrial cancer and findings are inconsistent.Methods: We studied associations between fish and meat intakes and endometrial cancer incidence in the large, prospective National Institutes of Health-AARP Diet and Health Study. Intakes of meat mutagens 2-amino-1-methyl-6-phenylimidazo4,5-b]pyridine (PhIP), 2-amino-3,8-dimethylimidazo4,5-f]quinoxaline (MeIQx), 2-amino-3,4,8-trimethylimidazo4,5-f]quinoxaline (DiMeIQx) and benzo(a)pyrene (BaP) were also calculated. We used Cox proportional hazards regression models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).Results: We observed no associations with endometrial cancer risk comparing the highest to lowest intake quintiles of red (HR=0.91, 95% CI 0.77–1.08), white (0.98, 0.83–1.17), processed meats (1.02, 0.86–1.21) and fish (1.10, 95% CI 0.93–1.29). We also found no associations between meat mutagen intakes and endometrial cancer.Conclusion: Our findings do not support an association between meat or fish intakes or meat mutagens and endometrial cancer. |
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| Keywords: | endometrial cancer meat fish meat mutagens epidemiology |
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