Survival analysis of high-intensity focused ultrasound ablation in patients with small hepatocellular carcinoma |
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Authors: | Tan To Cheung Sheung Tat Fan Ferdinand S K Chu Caroline R Jenkins Kenneth S H Chok Simon H Y Tsang Wing Chiu Dai Albert C Y Chan See Ching Chan Thomas C C Yau Ronnie T P Poon Chung Mau Lo |
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Institution: | 1.Department of Surgery, The University of Hong Kong, Hong Kong, China;2.State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong, China;3.Department of Anaesthesiology, The University of Hong Kong, Hong Kong, China;4.Department of Radiology, Queen Mary Hospital, Hong Kong, China |
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Abstract: | BackgroundHigh-intensity focused ultrasound (HIFU) ablation is a non-invasive treatment for hepatocellular carcinoma (HCC). At present, data on the treatment''s long-term outcome are limited. This study analysed the survival outcome of HIFU ablation for HCCs smaller than 3 cm.Patients and methodsForty-seven patients with HCCs smaller than 3 cm received HIFU treatment between October 2006 and September 2010. Fifty-nine patients who received percutaneous radiofrequency ablation (RFA) were selected for comparison. The two groups of patients were compared in terms of pre-operative variables and survival.ResultsMore patients in the HIFU group patients had Child–Pugh B cirrhosis (34% versus 8.5%; P = 0.001). The 1- and 3-year overall survival rates of patients whose tumours were completely ablated in the HIFU group compared with the RFA group were 97.4% versus 94.6% and 81.2% versus 79.8%, respectively (P = 0.530). The corresponding 1- and 3-year disease-free survival rates were 63.6% versus 62.4% and 25.9% versus 34.1% (P = 0.683).ConclusionsHIFU ablation is a safe and effective method for small HCCs. It can achieve survival outcomes comparable to those of percutaneous RFA and thus serves as a good alternative ablation treatment for patients with cirrhosis. |
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