2型糖尿病合并高脂血症患者颈动脉内膜-中层厚度与动脉弹性的相关性研究

目的 应用血管内中膜分析技术(QIMT)和动脉僵硬度分析技术(QAS)评价2型糖尿病合并高脂血症患者颈动脉内膜-中层厚度与弹性的相关性.方法 随机选取2型糖尿病合并高脂血症患者56例作为病例组,48例同期健康志愿者为对照组.应用QIMT和QAS技术对颈动脉进行检查,获得颈动脉的内膜-中层厚度(IMT)、顺应性系数(CC)、扩张性系数(DC)、僵硬度系数(β).病例组再根据IMT分组;IMT＜0.9 mm为病例1组,IMT≥0.9 mm为病例2组.结果 对照组、病例1组、病例2组的β、甘油三酯(TG)、低密度脂蛋白(LDL)、胆固醇(Ch)、糖化血红蛋白(GHb)、颈动脉IMT等指标差异有统计学意义(P＜0.05),对照组＜病例1组＜病例2组.对照组、病例1组、病例2组的DC、CC差异有统计学意义(P＜0.05),对照组＞病例1组＞病例2组.病例组的β与年龄、GHb、LDL和颈动脉IMT呈明显正相关,β与年龄r=0.811,P=0.000;β与GHbr=0.764,P:0.000;β与LDLr=0.732,P=0.000;β与颈动脉IMT r=0.729,P=0.000.结论 QIMT可较准确地测量颈动脉IMT,QIMT与QAS技术联合应用使颈动脉的解剖结构成像与功能成像有机地结合,可成为深入研究颈动脉早期结构和功能改变的有效手段.

Assessments of correlation between intima-media thickness and elasticity of carotid in patients with type 2 diabetes accompanied hyperlipidemia

Objective To investigate the correlation between intima-media thickness(IMT)and elasticity of carotid in patients with type 2 diabetes accompanied hyperlipidemia by quantitative intima-media thickness(QIMT)and quantitative arterial stiffness(QAS)technique.Methods Fifty-six patients with type 2 diabetes accompanied hyperlipidemia were involved into the study as case group.Forty-eight healthy volunteers were supplied as normal control group in the same period.IMT,compliance coefficient(CC),distensibility coefficient(DC)and stiffness index(β)of carotid were acquired through QIMT and QAS.Case group was divided into case group 1(IMT＜0.9mm)and case group 2(IMT≥0.9 mm),and analysis was performed furtherly.Results β,triglyceride(TG),lowdensity lipoprotein(LDL),cholesterol(Ch),glycosylated hemoglobin(GHb)and IMT had significant differences in case group 1,case group 2 and control group(P＜0.05),control group＜case group 1＜case group 2.DC and CC had significant differences in case group 1,case group 2 and control group(P＜0.05),control group＞case group 1＞case group 2.There was significant positive correlation between β and age,GHb,LDL and IMT of carotid respectively(r=0.811,r:0.764,r=0.732,r:0.729,respectively,P=0.000).Conchmions IMT of carotid could be measured accurately by QIMT.Structure imaging and functional imaging of carotid might be combined organically through QIMT and QAS.Depth study about early change of carotid in structure and function could be performed with these two techniques.