Verrucamides A-D, antibacterial cyclopeptides from Myrothecium verrucaria |
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Authors: | Zou Xianwei Niu Shubin Ren Jinwei Li Erwei Liu Xingzhong Che Yongsheng |
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Affiliation: | Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People's Republic of China. |
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Abstract: | Four new cyclic tetradecapeptides, verrucamides A-D (1-4), have been isolated from the solid-substrate fermentation culture of the ascomycete fungus Myrothecium verrucaria. The structures of these compounds, each featuring six N-methylated amino acid residues, were elucidated primarily by NMR and MS methods. The absolute configurations of 1-4 were assigned by application of Marfey's method on their acid hydrolysates. Compounds 1-4 showed antimicrobial activity against the Gram-positive bacterium Staphylococcus aureus. |
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