6，7-双乙酰化黄芩素在大鼠体内的代谢产物研究

研究6，7-双乙酰化黄芩素在大鼠体内的代谢产物。大鼠灌胃给予6，7-X2K,酰化黄芩素后，采用HPLC—DAD和LC／MS^n方法，检测大鼠肠内和血浆中的代谢产物。6,7-双乙酰化黄芩素在大鼠肠内降解为6-单乙酰黄芩素和黄芩素；在大鼠血浆中检测到4种葡萄糖醛酸苷类代谢产物，初步鉴定为6-O-葡萄糖醛酸黄芩素，6-O-甲基-7-O-葡萄糖醛酸黄芩素，6，7-O-双葡萄糖醛酸黄芩素和6-O-葡萄糖-7-O-葡萄糖醛酸黄芩素。首次报道了6，7-双乙酰化黄芩素在大鼠体内的药物代谢，在肠内和血浆中共鉴定了六个代谢产物。

Metabolites of baicalein 6,7-diacetate in rats

To investigate the metabolites of baicalein 6,7-diacetate in rats.HPLC-DAD and LC/MS~n methods were used to analyze the metabolites in intestinal tract and plasma after oral administration of baicalein 6,7-diacetate to rats.Baicalein 6,7-diacetate was degraded into baicalein 6-monoacetate and baicalein in rat intestinal tract,and four baicalein glucuronides,baicalein 6-O- glucuronide,baicalein 6-methoxyl-7-O-glucuronide,baicalein 6,7-di-O-glucuronide,and baicalein 6-O-glucose-7-O-glucuronide were detected and tentatively identified in rat plasma.This is the first time to report the metabolites of baicalein 6,7-diacetate in rats.Six metabolites were identified in rat intestinal tract and plasma.