Altered serotonin 2C receptor RNA splicing in suicide: association with editing |
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Authors: | Dracheva Stella Chin Benjamin Haroutunian Vahram |
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Institution: | Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA. Stella.Dracheva@mssm.edu |
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Abstract: | In an earlier study, we showed increases in serotonin 2C receptor (5-HT2CR) pre-mRNA editing in prefrontal cortex that were specific to suicide victims irrespective of associated psychiatric diagnoses. Here we demonstrate that the ratio between the two 5-HT2CR splice variants is increased in people who committed suicide, but does not vary among the diagnostic groups. This provides further evidence for suicide-specific neurobiology and suggests that, as it was previously shown in vitro, 5-HT2CR editing modulates its splicing in human brain. The association analysis indicates, however, that the efficiency of 5-HT2CR editing is an imperfect predictor of the splicing outcome, and that splice site selection is only partially controlled by the level of editing in vivo. |
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