同种输血对食管癌患者一氧化氮生成的影响

目的　探讨同种输血对食管癌手术患者一氧化氮 (NO)生成的影响。方法　食管癌手术患者 18名 ,以输注去白细胞血液的食管癌手术患者为实验对照 ,以 2 0名健康志愿者为正常对照 ,采用硝酸还原酶法检测血清中NO3 -/NO2 -来反映NO生成水平。结果　①食管癌患者的血清中NO3 -/NO2 -浓度与正常人相比无差异。②实验组输血后第 1天与输血前相比血清中NO明显降低 (P <0 .0 1) ,并显著低于实验对照组 (P <0 .0 1)。结论　食管癌患者围手术期同种输血可导致血清中NO浓度降低 ,而输注去白细胞血液患者血清中NO浓度下降不明显。因此 ,食管癌患者围手术期输注去白细胞血液明显优于输注常规血液

Study of Production of NO Resulting from Perioperative Allogeneic Transfusion in Esophageal Cancer Patients

Objective To study production of NO in esophageal cancer patients exposed to allogeneic transfusion by testing NO before and after allogeneic transfusion.Methods Serum NO 3 -/NO 2 -of 18 esophageal cancer patients undergoing transthoracic esophageal resection who received allogeneic transfusion were measured to compare with that of 16 patients undergoing but same operation but leukoreduced blood and 20 healthy volunteers.Results 1.Serum NO 3 -/NO 2 -levels in esophageal cancer patients were not different from those of volunteers.2.Serum NO 3 -/NO 2 -of the patients exposed to non leukoreduced allogeneic blood decreased on the first day after transfusion ( P <0.01),and were significantly lower than those in the patients who were exposed to leukoreduced blood( P <0.01).Conclusion Perioperative allogeneic transfusion of esophageal cancer patients resulted in decrease of serum NO 3 -/NO 2 -.However,the transfusion of leucocyte depleted blood did not result in this effect.So transfusion of leukoreduced blood may be beneficial to esophageal cancer patients undergoing operation.