| HPLC-MS/MS法同时测定止咳平喘类中成药中非法添加化学药物 |
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| 引用本文： | 孙晓,李卓,荀英,王涛,朱群英,张亚锋.HPLC-MS/MS法同时测定止咳平喘类中成药中非法添加化学药物[J].中成药,2019(10):2405-2409. |
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| 作者姓名： | 孙晓 李卓 荀英 王涛 朱群英 张亚锋 |
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| 作者单位： | 1.西安市食品药品检验所;2.渭南市中医医院;3.陕西省药品技术查验中心 |
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| 基金项目： | 陕西省科学技术厅重点研发计划(2017SF-311) |
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| 摘 要： | 目的建立高效液相色谱-串联质谱(HPLC-MS/MS)法同时测定止咳平喘类中成药制剂中非法添加的13种化学药物(茶碱、磺胺甲噁唑、甲氧苄啶、马来酸氯苯那敏、盐酸苯海拉明、盐酸氨溴索、枸橼酸喷托维林、硫酸特布他林、沙丁胺醇、地西泮、盐酸克伦特罗、异丙喘宁、盐酸麻黄碱)。方法样品甲醇提取物的分析采用资生堂(Shiseido)MGⅢC18柱(150 mm×2.1 mm,1.8μm);流动相甲醇-0.1%甲酸,梯度洗脱;体积流量0.3 mL/min;柱温30℃。电喷雾离子源正离子扫描(ESI+),多反应监测模式检测(MRM)。结果 13种化学药物在各自范围内线性关系良好(r≥0.998 0),平均加样回收率93.1%~112%,RSD均小于3.6%,检测限0.06~6.23 mg/kg,定量限0.20~16.3 mg/kg。10份样品中有3份检出有非法添加现象,添加物分别是盐酸克仑特罗、马来酸氯苯那敏、盐酸麻黄碱。结论该方法前处理简单快捷,测定灵敏度高,结果准确,适用于止咳平喘类中成药制剂中非法添加化学药物的检测。
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| 关 键 词： | 止咳平喘中成药 化学药物 HPLC-MS/MS |
Simultaneous determination of illegally added chemical drugs in cough-relieving Chinese traditional patent medicines by HPLC-MS/MS |
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| SUN Xiao,LI Zhuo,XUN Ying,WANG Tao,ZHU Qun-ying,ZHANG Ya-feng.Simultaneous determination of illegally added chemical drugs in cough-relieving Chinese traditional patent medicines by HPLC-MS/MS[J].Chinese Traditional Patent Medicine,2019(10):2405-2409. |
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| Authors: | SUN Xiao LI Zhuo XUN Ying WANG Tao ZHU Qun-ying ZHANG Ya-feng |
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| Institution: | (Xi'an Municipal Institute for Food and Drug Control, Xi'an 710054, China;Weinan Hospital of Traditional Chinese Medicine, Weinan 714000,China;Shannxi Provincial Examination Center of Pharmaceutical Technology, Xi'an 710054, China) |
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| Abstract: | |
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| Keywords: | cough-relieving Chinese traditional patent medicines chemical drugs HPLC-MS/MS |
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