金水宝胶囊联合厄贝沙坦对糖尿病肾病患者的临床疗效

目的探讨金水宝胶囊联合厄贝沙坦对糖尿病肾病患者的临床疗效。方法 82例患者随机分为观察组和对照组,每组41例。对照组给予厄贝沙坦,观察组在对照组基础上加用金水宝胶囊,4周为1个疗程。然后,分析总有效率、空腹血糖、收缩压、舒张压、血管内皮功能指标、细胞因子、生活质量量表评分变化。结果观察组总有效率显著高于对照组(P<0. 05)。治疗后,2组空腹血糖、收缩压、舒张压、ET-1、TNF-α、IL-6显著降低(P<0. 05),NO、生活质量量表评分显著升高(P<0. 05),以观察组更显著(P<0. 05)。结论金水宝胶囊联合厄贝沙坦临床疗效良好,可有效改善糖尿病肾病患者血管内皮功能、细胞因子水平、生活质量。

Clinical effects of Jinshuibao Capsules combined with irbesartan on patients with diabetic nephropathy

AIM To explore the clinical effects of Jinshuibao Capsules combined with irbesartan on patients with diabetic nephropathy. METHODS Eighty-two patients were randomly divided into control group for an intervention of 4-week irbesartan and observation group for 4-week Jinshuibao Capsules on the basis of irbesartan,41 cases in each group. Subsequently,the changes in total effective rate,fasting blood glucose,systolic blood pressure,diastolic blood pressure,vascular endothelial function indices,cytokines and life quality scale scores were analyzed. RESULTS The observation group demonstrated significantly higher total effective rate than the control group( P< 0. 05). Both groups shared markedly decrease in post-treatment fasting blood glucose,systolic blood pressure,diastolic blood pressure,ET-1,TNF-α and IL-6( P<0. 05),obvious improvement of NO and life quality scale scores( P < 0. 05), among which the observation group demonstrated its superiorities( P < 0. 05).CONCLUSION The combination therapy of Jinshuibao Capsules and irbesartan shed light on the treatment of diabetic nephropathic patients as revealed by the good clinical outcome of improvement in vascular endothelial function,cytokine levels and life quality.