部分多模态MRI在重度抑郁症中的研究进展

重度抑郁症是最常见的高致残性的精神疾病之一,其发病机制尚不清楚。MRI技术作为非侵入性的神经影像技术,可揭示重度抑郁症患者大脑功能状态。与健康对照者相比,重度抑郁症患者额叶、颞叶、海马、扣带回、基底节、小脑等脑区功能改变,可能提示重度抑郁症的病理生理异常。现就多模态MRI,包括弥散张量成像(DTI)、弥散峰度成像(DKI)、磁共振波谱成像(MRS)、功能MRI(fMRI)、神经突方向分散度和密度成像(NODDI)在重度抑郁症中的最新研究成果进行综述,以期对其神经生物学机制有更充分的理解。

Research progress of partial multimodal MRI in major depressive disorder

Major depressive disorder(MDD)is one of the most commonwith high disability,and its pathogenesis is still unclear.As a noninvasive neuroimaging technique,MRI can reveal the brain function of patients with severe depression.Compared with healthy controls,the functional changes of frontal lobe,temporal lobe,hippocampus,cingulate gyrus,basal ganglia,cerebellum and other brain areas in patients with severe depression may indicate the pathophysiological abnormalities of MDD.This article reviews the latest research results of multimodal MRI,including diffusion tensor imaging(DTI),diffusion kurtosis imaging(DKI),magnetic resonance spectroscopy(MRS),functional MRI(fMRI),neurite directional dispersion and density imaging(noddi)in MDD,in order to have a better understanding of its neurobiological mechanism.