竞争性内源性RNA与胃癌的相关研究进展

胃癌是全球最常见的癌症之一,是影响全球健康的一个主要问题。胃癌的发生发展是一个多因素共同作用的结果。近年来,非编码RNA(non-coding RNA,ncRNA),特别是微小RNA(microRNA,mi RNA)和长链非编码RNA(long non-coding RNA,lncRNA),因在人类各种疾病中具有重要意义,包括癌症,而受到广泛关注。无疑,竞争性内源性RNA(competitive endogenous RNA,ceRNA)假说的提出为疾病中的基因调控作用提供了新思路。根据最新发现,本文描述了ceRNA在胃癌发生、发展中的作用和意义,并探讨了ceRNA在胃癌中的相互作用及其可能的分子机制。

Advances in research on correlation between competitive endogenous RNA and gastric cancer

Gastric cancer is one of the most common cancers in the world and a major problem affecting global health.The occurrence and development of gastric cancer is the result of a combination of multiple factors.In recent years,non-coding RNAs(ncRNAs),especially microRNAs(miRNAs)and long non-coding RNAs(lncRNAs),are important in various human diseases including cancer,and have received widespread attention.Undoubtedly,the proposal of competitive endogenous RNA(ceRNA)hypothesis provides a new idea for gene regulation in diseases.Based on the latest findings,this article describes the role and significance of ceRNA in the development and progression of gastric cancer,and explores the interaction of ceRNA in gastric cancer and its possible molecular mechanisms.