微小RNA与抑郁症自杀机制及电休克疗法的研究进展

微小RNA的表达水平与抑郁症自杀方面具有重要的关联,与此同时电休克疗法也可能影响抑郁症相关的某些基因,并可能影响疗效。因此探究微小RNA与抑郁症自杀以及电休克疗法的相互作用机制成为非常有价值的研究领域。目前相关研究已取得一定的成果,也有亟待解决的问题,为此现对近年来研究发现的与抑郁症及其自杀相关的微小RNA表达特征,以及抑郁症对电休克疗法应答方面涉及的微小RNA进行回顾和综述。通过对相关文献的梳理与分析为未来的研究方向及临床应用提供借鉴。

Advances in the relationship between microRNAs and suicide diagnosis and treatment of depression

The expression levels of microRNAs have a significant relationship with suicide in depression,while electroconvulsive therapy may also affect certain genes associated with depression and may affect outcomes.Therefore,exploring the interaction mechanism between microRNAs and suicidal in depression and electroconvulsive therapy has become a very valuable research field.At present,some achievements have been made in related researches,and there are also some problems to be solved urgently.Therefore,this paper reviews the microRNAs expression characteristics related to depression and suicide,as well as the microRNAs involved in the response of depression to electroconvulsive therapy.Through sorting out and analyzing the related literature,it provides reference for future research direction and clinical application.