参黄凝胶膏剂中丁香挥发油对大黄酸的经皮渗透作用

目的探讨参黄凝胶膏剂中丁香挥发油对大黄酸的经皮渗透作用。方法采用改良Franz扩散池法,考察丁香挥发油对大黄酸透皮特性的影响。以大黄酸释放度为评价指标,立式扩散池结合透析袋法研究参黄凝胶膏剂体外释放行为。结果 3%丁香挥发油促透效果强于3%氮酮、3%薄荷挥发油,累积渗透量(120. 11±8. 84)μg/cm2,增渗倍数2. 93。体外释放行为与Weibull模型拟合度最高(r=0. 999 8)。结论丁香挥发油能显著增加参黄凝胶膏剂中大黄酸的透皮吸收。

Percutaneous penetration effects of Caryophylli Flos volatile oil on rhein in Shenhuang Gel Ointment

AIM To explore the percutaneous penetration effects of Caryophylli Flos volatile oil on rhein in Shenhuang Gel Ointment.METHODS Modified Franz diffusion cell method was applied to investigating the effects of Caryophylli Flos volatile oil on rhein transdermal characteristic.With rhein release rate as an evaluation index,vertical diffusion cell combined with dialysis bag method was used to study the in vitro release behaviors of Shenhuang Gel Ointment.RESULTS Three percent Caryophylli Flos volatile oil demonstrated stronger penetration enhancement effect than 3%azone and 3%Menthae haplocalycis Herba volatile oil,with the accumulative permeation quantity and enhancement ratio of(120.11±8.84)μg/cm2 and 2.93,respectively.The in vitro release behaviors exhibited the highest fitting degree with Weibull model(r=0.999 8).CONCLUSION Caryophylli Flos volatile oil can significantly increase the percutaneous absorption of rhein in Shenhuang Gel Ointment.