吗替麦考酚酯联合激素治疗血管炎性IgA肾病患者的临床效果分析

目的分析吗替麦考酚酯联合激素治疗血管炎性IgA肾病患者的临床效果。方法选取2016年3月～2018年6月期间我院收治的血管炎性IgA肾病患者40例为研究对象,随机分为研究组和对照组,每组20例。对照组在常规治疗基础上加用环磷酰胺、泼尼松,研究组在常规治疗基础上加用吗替麦考酚酯、泼尼松。观察两组临床治疗效果、治疗前后相关生化指标及尿量变化情况、药物所致不良反应发生情况。结果对照组治疗总有效率为70.0%,低于研究组的95.0%,差异有统计学意义(P0.05);治疗前两组血肌酐、白蛋白、总蛋白、24 h尿蛋白检测值及尿量比较,差异无统计学意义(P0.05),治疗后研究组血肌酐、24 h尿蛋白检测值较之前下降幅度以及白蛋白、总蛋白检测值及尿量较治疗前提高幅度均优于对照组,组间、组内数据比较,差异有统计学意义(P0.05);两组治疗期间药物相关不良反应发生情况比较,差异无统计学意义(P0.05)。结论吗替麦考酚酯、激素联合治疗血管炎性IgA肾病有效性、安全性均较优,值得临床应用以及推广。

Clinical effect analysis of mycophenolate mofetil combined with hormone in the treatment of patients with vasculitic IgA nephropathy

Objective To analyze the clinical effect of mycophenolate mofetil combined with hormone in the treatment of patients with vasculitic IgA nephropathy.Methods A total of 40 patients with vasculitic IgA nephropathy admitted in our hospital from March 2016 to June 2018 were enrolled in the study.They were randomly divided into study group and control group,with 20 cases in each group.The control group was given cyclophosphamide and prednisone on the basis of conventional treatment.The study group was added with mycophenolate mofetil and prednisone to the conventional treatment.The clinical treatment effects,the related biochemical indicators and urine volume changes before and after treatment,and the adverse reactions caused by drugs of the two groups were observed.Results The total effective rate of the control group was 70.0%,which was lower than that of the study group(95.0%).The difference was statistically significant(P<0.05).There was no significant difference in the detection value of the serum creatinine,albumin,total protein and 24 h urine protein,and urine volume before treatment(P>0.05).After treatment,the declining degree of serum creatinine and 24 h urine protein levels compared with that before treatment,and the albumin,total protein detection value and urine volume in the study group were better than those before treatment.There was statistically significant difference in data between and within groups(P<0.05).There was no significant difference in the incidence of drug-related adverse reactions between the two groups during treatment(P>0.05).Conclusion The combination of mycophenolate mofetil and hormone in the treatment of vasculitic IgA nephropathy is effective and safe,which is worthy of clinical application and promotion.