参麦注射液联合常规治疗对脓毒性休克患者的临床疗效

目的探讨参麦注射液联合常规治疗对脓毒性休克患者的临床疗效。方法 106例患者随机分为对照组和观察组,每组53例,对照组给予常规治疗,观察组在对照组基础上加用参麦注射液,7 d为1个疗程。然后,检测临床疗效指标[急性生理和慢性健康状况评分(APACHE-Ⅱ)、全身感染相关器官功能衰竭评分(SOFA)、乳酸(LA)]、心功能评价指标[平均动脉压(MAP)、心排血量(CO)、左室射血分数(LVEF)、心脏指数(CI)、每搏输出量(SV)、心率(HR)]、肾功能评价指标[24 h尿量、尿素氮(BUN)、肌酐(Cr)、尿酸(UA)]、血清炎性反应因子[C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、降钙素原(PCT)]变化。结果治疗后,2组临床疗效指标、HR、BUN、Cr、UA、血清炎性反应因子显著降低(P<0.01),MAP、CO、LVEF、CI、SV、24 h尿量显著升高(P<0.01),以观察组(24 h尿量除外)更明显(P<0.01)。结论参麦注射液联合常规治疗可改善脓毒性休克患者临床症状及心肾功能,降低血清炎性反应因子水平。

Clinical effects of Shenmai Injection combined with routine treatment on septic shock patients

AIM To explore the clinical effects of Shenmai Injection combined with routine treatment on septic shock patients.METHODS One hundred and six patients were randomly divided into control group and observation group,53 cases in each group,the control group was given routine treatment,while the observation group was added with Shenmai Injection on the basis of the control group,7 days as a course of treatment.Subsequently,the changes in clinical efficacy indices[acute physiology and chronic health evaluation Ⅱ(APACHE-Ⅱ)score,sequential organ failure assessment(SOFA)score,lactic acid(LA)],cardiac function evaluation indices[mean arterial pressure(MAP),cardiac output(CO),left ventricular ejection fraction(LVEF),cardiac index(CI),stroke volume(SV),heart rate(HR)],renal function evaluation indices[24 h urine volume,blood urea nitrogen(BUN),creatinine(Cr),uric acid(UA)] and serum inflammatory response factors[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),procalcitonin(PCT)] were detected.RESULTS After the treatment,the two groups demonstrated significantly decreased clinical efficacy indices,HR,BUN,Cr,UA and serum inflammatory response factors(P<0.01),and markedly increased MAP,CO,LVEF,CI,SV and 24 h urine volume(P<0.01),especially for the observation group(P<0.01,except for 24 h urine volume).CONCLUSION For the septic shock patients,Shenmai Injection combined with routine treatment can improve clinical symptoms,cardiac and renal functions,and decrease serum inflammatory response factor levels.