艾瑞昔布超前镇痛用于脊柱手术对患者术后镇痛效果的影响

目的观察艾瑞昔布超前镇痛用于脊柱手术对患者术后镇痛效果的影响。方法选取本院2017年3月～2018年3月收治的110例脊柱手术患者,按随机数表法分为观察组与对照组,各55例。观察组术前30 min口服100 mg的艾瑞昔布,对照组口服相同剂量的安慰剂。术毕予负荷剂量的芬太尼0.001 mg/kg。比较两组术后6 h与12 h的疼痛程度采用视觉模拟评分法(VAS)评估]、镇静效果(采用Ramesay评分法评估)、芬太尼消耗量、自控按压总次数、不良反应总发生率。结果观察组术后6 h与术后12 h的术后疼痛VAS评分分别为(2.80±0.82)分与(1.85±0.45)分,低于对照组的(3.15±0.91)分与(2.32±0.64)分;观察组的镇静Ramesay评分分别为(2.28±0.59)分与(2.06±0.58)分,低于对照组的(2.63±0.71)分与(2.33±0.70)分,差异有统计学意义(P0.05)。观察组术后0～6 h、6～12 h、12～24 h的芬太尼消耗量及自控按压总次数均低于对照组(P0.05)。观察组的不良反应总发生率为7.27%,低于对照组的21.82%(P0.05)。结论脊柱手术患者采用艾瑞昔布进行超前镇痛可获得良好的术后镇痛效果与镇静效果,芬太尼用量与不良反应均明显减少,具有较高的有效性与安全性,值得推广。

Effect of preemptive analgesia with ericoxib on postoperative analgesic effect in patients undergoing spinal surgery

Objective To observe the effect of preemptive analgesia with ericoxib on postoperative analgesic effect in patients undergoing spinal surgery.Methods A total of 110 patients with spinal surgery who were admitted in our hospital from March 2017 to March 2018 were enrolled and divided into the observation group and the control group,with 55 cases in each group.The observation group received 100 mg of ericoxib 30 min before surgery,and the control group received the same dose of placebo.The loading dose of fentanyl 0.001 mg/kg was used after surgery.The pain levels(measured by visual analog scale(VAS)),sedative effect(assessed by Ramesay score),fentanyl consumption,total number of controlled compressions,total adverse events rate at 6 h and 12 h after surgery between two groups were compared.Results The postoperative pain VAS scores of the observation group at 6 h and 12 h after surgery were(2.80±0.82)and(1.85±0.45),respectively,which were lower than(3.15±0.91)and(2.32±0.64)of the control group.The sedative Ramesay scores of observation group were(2.28±0.59)and(2.06±0.58),respectively,which were lower than(2.63±0.71)and(2.33±0.70)of the control goup,and the difference was statistically significant(P<0.05).The fentanyl consumption and the total number of controlled compressions in the observation group were lower than those in the control group at 0-6 h,6-12 h,12-24 h after surgery(P<0.05).The total incidence of adverse reactions in the observation group was 7.27%,which was lower than that in the control group(21.82%)(P<0.05).Conclusion Patients with spinal surgery can achieve good postoperative analgesic effect and sedative effect by using ericoxib for preemptive analgesia.The dosage of fentanyl and adverse reactions are significantly reduced.The analgesia method has high efficacy and safety,and is worthy of promotion.