耐碳青霉烯类铜绿假单胞菌分布方式以及耐药性研究

目的研究耐碳青霉烯类铜绿假单胞菌分布方式以及耐药性。方法随机选取2016年6月～2018年6月我院收治的住院患者的铜绿假单胞菌2288株,其中耐碳青霉烯类铜绿假单胞菌60株,占总数的2.6%。进行菌株培养和鉴定、药敏试验,然后分析耐碳青霉烯类铜绿假单胞菌的科室分布及耐药性。结果耐碳青霉烯类铜绿假单胞菌主要分布在重症监护室,占总数的50.0%;其次为神经外科,占总数的26.7%;再次为神经内科,占总数的13.4%;最后为呼吸科、骨科、普外科,均占总数的3.3%。耐碳青霉烯类铜绿假单胞菌对美罗培南、亚胺培南、氨曲南、哌拉西林、左氧氟沙星、庆大霉素的耐药性最高,均为100.0%;其次为妥布霉素、哌拉西林/他唑巴坦,耐药性均为96.7%;再次为头孢吡肟、头孢他啶、头孢哌酮/舒巴坦、环丙沙星,耐药性分别为93.3%、90.0%、90.0%、83.3%,最后为阿米卡星,耐药性为16.7%;对多黏菌素B不耐药,耐药性为0。结论耐碳青霉烯类铜绿假单胞菌分布较为集中,高度耐药于常见抗菌药物,实时监控耐碳青霉烯类铜绿假单胞菌感染患者能够对其在医院内传播进行有效预防。

Study on distribution pattern and drug resistance of carbapenem-resistant pseudomonas aeruginosa

Objective?To study the distribution pattern and drug resistance of carbapenem-resistant Pseudomonas aeruginosa.Methods?2288 strains of Pseudomonas aeruginosa were randomly selected from hospitalized patients admitted to our hospital from June 2016 to June 2018.Among them,there were 60 strains of carbapenem-resistant Pseudomonas aeruginosa,accounting for 2.6%of the total.The strain culture,identification,and drug sensitivity test were carried out,and the department distribution and drug resistance of carbapenem-resistant Pseudomonas aeruginosa were analyzed.Results?The carbapenem-resistant Pseudomonas aeruginosa was mainly distributed in the intensive care unit,accounting for 50.0%of the total,followed by the department of neurosurgery,accounting for 26.7%of the total,again followed by the department of neurology,accounting for 13.4%of the total;it was least distributed in the departments of respiratory medicine,orthopedics,and general surgery,accounting for 3.3%of the total.The carbapenem-resistant Pseudomonas aeruginosa showed the highest resistance to meropenem,imipenem,aztreonam,piperacillin,levofloxacin and gentamicin,with the drug resistance of 100.0%,followed by tobramycin,piperacillin/tazobactam,with the drug resistance of 96.7%,again followed by cefepime,ceftazidime,cefoperazone/sulbactam,ciprofloxacin,with the drug resistance of 93.3%,90.0%,90.0%,83.3%,respectively;it showed the least resistance to amikacin,with the drug resistance of 16.7%;it was not resistant to polymyxin B,with the drug resistance of 0.Conclusion?The distribution of carbapenem-resistant Pseudomonas aeruginosa is concentrated,which is highly drug resistant to common antibacterial drugs.Realtime monitoring of patients with carbapenem-resistant Pseudomonas aeruginosa infections can effectively prevent their transmission in hospitals.