皮质类固醇应用时机对细菌性角膜溃疡愈后的影响

目的：探讨细菌性角膜溃疡在有效抗生素控制感染后的不同时机局部应用皮质类固醇激素对溃疡灶修复的影响。方法：对70例细菌性角膜渍疡在有效抗生素控制感染，渍疡浸润控制，渍疡缘增生隆起发生后分组分剐不应用及不同时段应用皮质类固醇激素治疗，对比愈后。结果：治疗1组对比对照组角膜溃疡修复时间缩短，愈后瘢痕及新生血管减轻，视力提高均有显著差异（P〈0．001）；治疗1组对比治疗2组角膜溃疡修复时间明显缩短（P〈0．001），愈后新生血管减轻，视力提高有统计学差异（P〈0．05）。结论：细菌性角膜溃疡在有效抗生素控制感染后及时应用皮质类固醇激素能促进角膜溃疡的愈合及减轻愈后瘢痕和新生血管生成，从而提高视力。

INFLUNCEN OF APPLICATION OF CONTICOSTERLID TO CORNEAL ULCER ON ITS PROGNOSIS

Objective： To investigate the topcical usage of corticosteroid on the recovery of ulcer in bacterila corneal ulcer after systemic treatment with antibiotics. Methods：70 patients were first treated with antibiotics to control the infection, topcical eorticosteroid was then used in the hyperplasy tissues at certain stages. Results： the reparation of corneal ulcer was shortened, scar and new vessels were decreased, eyesight was improved in patient with treatment 1 （ p 〈 0. 001 ） ; there was siginificantly different between treatment group 1 and group 2 （ p 〈 0.001 ）. Conclusion： after systemic treatment with antibiotic, topcical usage of corticosteroid was a effective way to improve reparation of corneal ulcer, inhibit the formation of scar and new vessels, and then improve eyesight.