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Linear response of mutans streptococci to increasing frequency of xylitol chewing gum use: a randomized controlled trial [ISRCTN43479664] |
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| Authors: | Kiet A Ly Peter Milgrom Marilyn C Roberts David K Yamaguchi Marilynn Rothen Greg Mueller |
| Affiliation: | (1) Northwest/Alaska Center to Reduce Oral Health Disparities, Department of Dental Public Health Sciences, Box 357475, University of Washington, Seattle, WA 98195, USA;(2) Department of Pathobiology, University of Washington, Seattle, WA 98195, USA;(3) Regional Clinical Dental Research Center, University of Washington, Seattle, WA 98195, USA |
| Abstract: | BackgroundXylitol is a naturally occurring sugar substitute that has been shown to reduce the level of mutans streptococci in plaque and saliva and to reduce tooth decay. It has been suggested that the degree of reduction is dependent on both the amount and the frequency of xylitol consumption. For xylitol to be successfully and cost-effectively used in public health prevention strategies dosing and frequency guidelines should be established. This study determined the reduction in mutans streptococci levels in plaque and unstimulated saliva to increasing frequency of xylitol gum use at a fixed total daily dose of 10.32 g over five weeks. |
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