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Randomized, Evaluator-Blind, Split-Face Comparison Study of Single Cross-linked versus Double Cross-linked Hyaluronic Acid in the Treatment of Glabellar Lines |
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| Authors: | TARO KONO MD PHD BRIAN M. KINNEY SM MD WILLIAM FREDERICK GROFF DO HENRY H. CHAN MD FRCP ALI RIZA ERCOCEN MD MOTOHIRO NOZAKI MD PHD |
| Affiliation: | Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical University, Tokyo, Japan;;Department of Plastic Surgery, University of California at Los Angeles, Los Angeles, California;;Division of Cosmetic Dermatology, La Jolla Cosmetic Surgery Centre, La Jolla, California;;Division of Dermatology, Department of Medicine, University of Hong Kong, Hong Kong;;Department of Medicine/Therapeutic and Pediatric, Chinese University of Hong Kong, Hong Kong;;Department of Plastic, Reconstructive and Aesthetic Surgery, Cumhuriyet University Faculty of Medicine, Sivas, Turkey |
| Abstract: | BACKGROUND At present, various hyaluronic acids are being used to rejuvenate facial skin. There is no comparative study of single cross-linked hyaluronic acid (SCHA) versus double cross-linked hyaluronic acid (DCHA). The objective of our study is to compare the effectiveness and complications of SCHA versus DCHA in the treatment of glabellar lines. METHODS Ten female patients were enrolled in this randomized, evaluator-blind study. One side (left vs. right) of each patient's glabellar lines was treated with SCHA and the other side was treated with DCHA. Two independent blinded observers reviewed the clinical photographs at 3, 6, 9, and 12 months after the treatment and assessed for degree of improvement as well as complications. RESULTS The two products were equally effective in producing an optimal cosmetic result, although at 6, 9, and 12 months posttreatment, a higher proportion of patients showed over 50% improvement with DCHA than with SCHA. At 12 months posttreatment, DCHA was considered superior in 70% of patients, whereas SCHA was superior in 10% of patients. CONCLUSIONS Both SCHA and DCHA are equally effective in producing an optimal cosmetic result. DCHA provides a more durable esthetic improvement when compared to SCHA in the treatment of glabellar lines. |
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