| 碱性成纤维细胞生长因子促进缺血皮瓣微循环重建的实验研究 |
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| 引用本文： | 呙长模,张英,张代禄. 碱性成纤维细胞生长因子促进缺血皮瓣微循环重建的实验研究[J]. 中华整形外科杂志, 1998, 0(4) |
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| 作者姓名： | 呙长模 张英 张代禄 |
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| 作者单位： | 重庆医科大学临床学院 |
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| 摘 要： | 目的探讨碱性成纤维细胞生长因子对缺血皮瓣微循环重建的影响。方法以Ｗｉｓｔａｒ大鼠为实验动物，在其背部形成７ｃｍ×１ｃｍ随意皮瓣，通过测定皮瓣存活面积、病理切片、电镜观察、组织化学染色、图像分析技术等手段进行观察。结果给药组以毛细血管增生为特征，微血管断面面积及皮瓣存活率均显著高于对照组。结论碱性成纤维细胞生长因子可促进缺血皮瓣微循环重建。
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| 关 键 词： | 碱性成纤维细胞生长因子 缺血皮瓣 微循环 |
An experimental study on promoting reconstruction of microcirculation of the ischemic skin flap with basic fibroblast growth factor |
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| Guo Changmo,Zhang Ying,Zhang Dailu,et al.. An experimental study on promoting reconstruction of microcirculation of the ischemic skin flap with basic fibroblast growth factor[J]. Chinese journal of plastic surgery, 1998, 0(4) |
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| Authors: | Guo Changmo Zhang Ying Zhang Dailu et al. |
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| Affiliation: | Guo Changmo,Zhang Ying,Zhang Dailu,et al.Clinical College of Chongqing Medical University,Chongqing 400042 |
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| Abstract: | Objective This study was to determine whether the basic fibroblast growth factor (bFGF) could promote reconstruction of microcirculation in the ischemic portion of a random skin flap.Methods Five methods were used in the experiment:measurement of the survival area of the skin flap;light and electron microscopic studies;immunohistochemical observation of the endothelial cell and microvessel image analysis technology (IAT).Result The survival area and microvessels in the skin flap were significantly increased in the treated group.The results indicate that bFGF can stimulate the proliferation and differentiation of endothelial cells in vivo and promote the microcirculation of the ischemic flap.Conclusion bFGF could promote reconstruction of microcirculation of the ischemic skin flap. |
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| Keywords: | Basic fibroblast growth factor Ischemic skin flap Microcirculation |
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