| Abstract: | The level of cytokines produced by ConA activated splenocytes was studied in male BALB/c and C57Bl/6 mice after single and repeated cold exposure (–20°C, 3 min). Single cold exposure significantly decreased IL-2, -3, -4, -5, -10, -12, IFN- production in BALB/c mice and decreased IL-2 content and increased TNF- level in C57Bl/6 mice. Repeated cold exposure normalized the content of IL-2, -4, -10, -12, and IFN- in BALB/c mice, which reflects the development of adaptive immune reactions. In C57Bl/6 mice IL-2, -3, -5, -10, -12, and IFN- production remained significantly decreased, which attested to dysadaptive processes.__________Translated from Byulleten Eksperimentalnoi Biologii i Meditsiny, Vol. 139, No. 2, pp. 188–190, February, 2005 |
