肝病患者干眼症患病情况分析

目的分析肝病患者干眼症患病情况。方法收集2011年1—5月就诊于首都医科大学附属北京佑安医院眼科中心并经该院肝病专科医师确诊的肝病患者31例(62眼),年龄23～73岁,平均(49.9±12.8)岁。所患肝病包括甲型肝炎、乙型肝炎、丙型肝炎等肝脏疾病。所有研究对象均除外眼部外伤、手术及眼部屈光激光手术史,未曾配戴角膜接触镜,无眼睑及眼球位置异常及其他眼部疾病史。进行干眼症状的问卷调查,观察指标包括泪液分泌(Schirmer I)试验、泪膜破裂时间(break up tmie,BUT)和角膜染色。结果肝病患者干眼症为23例(74.19%);问卷调查阳性者20例(64.52%);Schirmer I试验显示:肝病患者为(5.42±5.19)mm,BUT检查(5.58±2.29)s,角膜荧光染色评分(0.23±0.61)分;发生睑板腺阻塞者10例(16眼),占总患者数32.26%。结论肝病患者干眼症发病率高,应引起眼科医师重视,患者应定期进行相关检查,及早发现并治疗眼表疾病。

Analysis on prevalence rate of dry eye syndrome in patients with liver disease

[Objective] To investigate the prevalence rate of dry eye syndrome in the patients with liver disease.[Methods]31 patients（62 eyes） who were diagnosed by specialists in Ophthalmic Center of Beijing You＇an Hospital Affiliated to Capital University of Medical Sciences from January to May 2011 were collected.The patients were aged 23~73 years old,and the average was（49.9±12.8） years old.The liver diseases included hepatitis A,hepatitis B and hepatitis C.All patients had no history of eye injury,surgery and ocular refractive laser operation,did not wear corneal contact lens,no ocular eyelid abnormality and other eye diseases history.All patients received the questionnaire about dry eye symptoms,the observation indexes included Schirmer I test,tear film break-up time（BUT） and corneal staining.[Results]There were 23（74.19%） cases of dry eye syndrome.The questionnaire survey indicated that 20 cases（64.52%） had positive syndromes.Among liver disease patients,the result of Schirmer I test was（5.42±5.19） mm,BUT result was（5.58±2.29） s,and corneal staining score was（0.23±0.61）.10 cases（16 eyes） had meibomian gland obstruction,accounting for 32.26% of the total patients.[Conclusion]The incidence of dry eye syndrome is high among patients with liver disease,and the ophthalmologists should pay attention to it.Patients should receive the examination regularly,so as to early detect and treat the ocular surface diseases.