Five-year results of renal transplantation on immunosuppressive triple therapy with mycophenolate mofetil |
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Authors: | Offermann Gerd |
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Affiliation: | Department of Internal Medicine IV, Division of Endocrinology and Nephrology, Benjamin Franklin University Hospital, Free University of Berlin, Germany. gerd.offermann@medizin.fu-berlin.de |
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Abstract: | Mycophenolate mofetil (MMF) combined with cyclosporine and prednisolone significantly lowers acute rejection frequency in the early post-renal transplantation phase. To date only registry data with very high transplant numbers have shown that MMF significantly influences long-term outcome. A comparative retrospective analysis of the 5-yr results with MMF in a single transplant center was thus undertaken vs. other standard immunosuppressive regimens. The results of 1579 renal transplantations were grouped by treatment modality, subjected to Kaplan-Meier analysis, and compared using the log rank test. Both the total population and subgroups showed a non-significant trend towards better graft survival with MMF, evident at 2 yr and persisting for 5 yr. Extrapolation indicates that on combination therapy with MMF vs. azathioprine, approximately 10% more patients will be alive at 10 yr with a functional graft. |
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Keywords: | immunosuppression kidney graft survival kidney transplantation mycophenolate mofetil renal transplantation |
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