胸腺肽佐治原发性癫痫患儿临床疗效及免疫功能观察

目的：研究原发性癫痫患儿的免疫功能及胸腺肽佐治的临床疗效。方法：IL－2、SIL－2R及T淋巴细胞亚群测定采用ELISA及APAAP。50例健康儿童为对照组，64例患儿分为二组，采用抗癫痫药物治疗为治疗组1及抗癫痫药物加胸腺肽治疗为治疗组2。结果：治疗组与对照组比较，患儿IgA、CD3、CD4、CD4／CD8及IL－2活性明显降低；而SIL－2R水平明显升高（P均＜0．01），胸腺肽佐治癫痫患儿的治疗组2与对照组比较，IgA、CD3、CD4、CD4／CD8及IL－2活性明显升高，而SIL－2R水平明显降低（P均＜0．01）且胸腺肽佐治癫痫患儿的治疗有效率85．3％明显高于治疗组1的治疗有效率53．4％（P＜0．01）。结论：癫痫患儿免疫功能缺陷及紊乱，抗癫痫药物对患儿免疫功能没有明显影响，胸腺肽辅助治疗有助于患儿病情康复及免疫功能提高。

Clinical Observation on the Effectiveness of Thymus Peptide on Child Idiopathic Epilepsy

Objective: To study the effectiveness of thymus peptide on child idiopathic epilepsy. Methods: 64 cases of child idiopathic epilepsy were randomly devided into 2 experimental groups. Group 1 was treated by anti-epileptic drugs, Group 2 was treated by thymuspeptide as well as anti -epileptic drugs. Control group consisted of 50 healthy children. The levels of IL-2, SIL-2R and T 1ymphocyte subsets were tested with ELISA and APAAP. Results: The activities of IgA, CD3, CD4, CD4/CD8 and IL-2 in experimental group 1 prominently went down, but those in experimental group 2 prominently went up( P<0.01 ). The effective rate of experimental group 2 was prominently higher than experimental group 1. Conclusions: Thymus peptide is an effetive adjunant for child idiopathic epilepsy.