Cerebral laterality and the study of alcoholism |
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| Authors: | W P London |
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| Affiliation: | 1. Laboratory of Fungal Genetics and Metabolism, Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, CZ-14220 Prague, Czech Republic;2. Department of Botany, Faculty of Science, Charles University, Benátská 2, CZ-12801 Prague, Czech Republic;3. Laboratory of Structural Biology and Cell Signalling, Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, CZ-14220 Prague, Czech Republic;4. Biosystematics Division, Plant Protection Research Institute, Agricultural Research Council, Private Bag X134, Pretoria 0121, South Africa;1. Innaxis Foundation & Research Institute, José Ortega y Gasset 20, 28006 Madrid, Spain;2. Center for Computational Simulation, Universidad Politécnica de Madrid, 28223 Pozuelo de Alarcón, Madrid, Spain;3. Department of Engineering Sciences, University of Oxford, Parks Road, Oxford OX1 3PJ, UK;4. Departamento de Engenharia Electrotécnica, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Lisboa, Portugal;1. School of Telecommunications and Information Engineering, Nanjing University of Posts and Telecommunications, Nanjing 210003, Jiangsu, China;2. School of Mines, China University of Mining and Technology, Xuzhou 221116, Jiangsu, China;3. Department of Mining and Metallurgical Engineering, Western Australian School Mines, Curtin University, Kalgoorlie, WA, Australia;4. School of Geography and Biological Information, Nanjing University of Posts and Telecommunications, Nanjing 210023, Jiangsu, China;5. Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, Jiangsu, China;1. Sleep-Wake-Epilepsy-Center, Department of Neurology, Inselspital, Bern University Hospital, University Bern, Switzerland;2. Support Center for Advanced Neuroimaging (SCAN), Institute of Diagnostic and Interventional Neuroradiology, University Hospital, Inselspital, University of Bern, Switzerland;3. Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Spain;4. College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, UK;5. Centre for Biomedical Modelling and Analysis, University of Exeter, Exeter, UK;6. EPSRC Centre for Predictive Modelling in Healthcare, University of Exeter, Exeter, UK;7. Department of Neurosurgery, Inselspital, Bern University Hospital, University Bern, Switzerland;1. University Pablo de Olavide, Seville, Spain;2. University of Seville, Seville, Spain;3. University CEU San Pablo, Seville, Spain |
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| Abstract: | This paper suggests that the strategy of studying individuals at high risk to develop alcoholism by comparing, for example, sons of alcoholic fathers with sons of nonalcoholic fathers might not control for handedness or for patterns of cerebral laterality. In our sample of alcoholic men, at least 50% of the men left-handed or having a left-handed first-degree relative had an alcoholic father, versus only 26% of the right-handed men not having a left-handed first-degree relative. If generalized to nonalcoholic individuals, these data suggest that a larger proportion of the sons of alcoholic fathers either would be left-handed or would have a left-handed first-degree relative, and might have an anomalous pattern of cerebral dominance. Furthermore, several findings associated with being at high risk for alcoholism have also been associated with left-handedness or with left-hemisphere dysfunction. |
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