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正常妊娠妇女凝血、抗凝与纤溶指标的测定及意义
引用本文:徐成伟,范廷英,赵昌盛,时晓华,李莹,王正起. 正常妊娠妇女凝血、抗凝与纤溶指标的测定及意义[J]. 微循环学杂志, 2003, 13(2): 40-40,51
作者姓名:徐成伟  范廷英  赵昌盛  时晓华  李莹  王正起
作者单位:山东大学第二医院,济南,250033
摘    要:目的 :探讨孕妇妊娠期机体凝血、抗凝、纤溶系统的改变及其生理和病理意义。方法 :凝固法测定凝血酶原时间 (PT)、活化部分凝血活酶时间 (APTT)和凝血酶时间 (TT) ;发色底物法测定纤维蛋白原 (Fib)、抗凝血酶Ⅲ (AT Ⅲ )、蛋白C(PC)和蛋白S(PS) ;ELISH法测定纤维蛋白降解产物 (FDP)和D 二聚体 (D D)。结果 :5 0例妊娠 2 8~ 32周的孕妇 (妊娠组 )与 5 0例正常非孕妇女 (对照组 )相比 ,妊娠组凝血指标PT、APTT、TT时间 ( 9.6 0s± 2 .5 4s、2 8.90s± 3.75s、11.6s± 3.5 4s)显著缩短 (对照组分别是 12 .10s± 2 .15s、31.5 0s±4 .4 6s、4 .2 0s± 2 .18s) ;孕妇组抗凝指标AT Ⅲ、PC、PS活性 ( 88.75 %± 13.4 7%、91.85 %± 2 5 .32 %、89.6 4 %± 19.88% )明显降低 (对照组分别是 99.5 5 %± 11.2 4 %、10 4 .33%±32 .88%、10 3.5 6 %± 2 2 .5 8% ) ;Fib、FDP、D D含量均明显升高 (P <0 .0 5或P <0 .0 1)。结论 :妊娠期妇女凝血、抗凝及纤溶功能发生改变 ,表现为凝血功能增强 ,抗凝功能降低 ,出现所谓妊娠期高凝状态。这一妊娠期生理变化为产后快速有效止血提供了物质基础 ,但也可能是导致妊娠期血栓病发生的重要原因

关 键 词:凝血  抗凝  纤溶  妊娠  高凝状态

Meaning on Measurement of Coagulative and Anticoagulative and Fibrinolyic Indexes in Normal Pregnancy
Xu Chengwei,Fan Tingying,Zhao Changsheng,et al/The Second Hospital of Shandong University,Jinan. Meaning on Measurement of Coagulative and Anticoagulative and Fibrinolyic Indexes in Normal Pregnancy[J]. Chinese Journal of Microcirculation, 2003, 13(2): 40-40,51
Authors:Xu Chengwei  Fan Tingying  Zhao Changsheng  et al/The Second Hospital of Shandong University  Jinan
Affiliation:Xu Chengwei,Fan Tingying,Zhao Changsheng,et al/The Second Hospital of Shandong University,Jinan 250033
Abstract:Objective: To explore the clinical signification of coagulation indexes(PT?APTT?TT)?anti coagulation indexes(AT Ⅲ?PC?PS) and fibrinolysis indexes(FDP?D D) in normal pregnancy women.Method: PT?APTT?TT were assayed using coagulation method;AT Ⅲ?PC?PS were determined by chromogenic substances;and FDP?D D were measured with ELISA Kits.Results: 50 normal women controls(NC group) and 50 normal pregnancy women at the gestation periodin in 28~32 week′s (NP group) were measured.It showed that the coagulation time of PT?APTT?TT were significant decreased,the plasma activity of AT Ⅲ?PC?PS were much lower and the plasma content of FDP?D D were significant increased in NP group than that in NC group respectively.Conclusion: The normal pregancy women have a much changes in coagulation/fibrinolyic system,showing a pregnancy related hypercoagulate state existing in normal pregnancy women with a risk of thrombotic complication.
Keywords:Coagulation  Anti coagulation  Fibrinolysis  Pregnancy  Hypercoagulative condition  
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