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Regional coupling of blood flow and methionine uptake in an experimental tumor assessed with autoradiography |
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| Authors: | Yoshinao Abe Taiju Matsuzawa Masatoshi Itoh Kiichi Ishiwata Takehiko Fujiwara Tachio Sato Keiichiro Yamaguchi Tatsuo Ido |
| Affiliation: | (1) Department of Radiology and Nuclear Medicine, Research Institute for Tuberculosis and Cancer, Tohoku University, 4-1 Seiryo-machi, 980 Sendai, Japan;(2) Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan |
| Abstract: | Regional distribution of L-[methyl-14C] methionine (14C-MET) and 4-[18F] fluoro-antipyrine was compared using experimental rat tumors (AH109A) and a computerized autoradiogram image processor. Tissue distributions of the two tracers were found to be inhomogeneous in the tumor with nearly identical image patterns. Analysis of tissue radioactivities revealed that 82% of 14C-MET was derived from the acid insoluble fraction at 60 min after injection. The present study showed that 14C-MET uptake closely relates to tissue blood flow and may depend on its blood to tissue transport. Rapid incorporation of MET in the acid insoluble fraction implies that it is rapidly metabolized after transport into tumor tissue. |
| Keywords: | Blood flow Methionine uptake Rat Tumor Autoradiography |
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