支气管哮喘发病机制研究进展

支气管哮喘的发病率和病死率有逐年上升的趋势。近年来对其发病机制的认识也发生了根本性的变化,已认识到它是一种慢性气道炎性疾病。气道慢性炎症、气道高反应性和可逆性气道阻塞是其特点。哮喘发病机制十分复杂,涉及许多方面。近几年对哮喘的发病机制在细胞水平、分子水平和基因水平进行了大量深入研究,发现哮喘的发病和诸多免疫细胞、众多细胞因子、多种生物介质以及遗传因素有关。本文主要就免疫学机制、神经机制、遗传因素予以综述。

Research Development on Mechanism of Bronchial Asthma

The disease ineidenee and ease-fatality rate of the bronchial asthma has been ascending gradually. In reeent daeades the eognition of the meehanism of bronchial asthma has essentialitily changed, which is known as ehronie airway inflammatory disease. Airway chronic inflammatio, airway hyperreaetivity, reversability airway obstruction are the feature of the bronchial asthma. The meehanism of bronchial asthma is muhipieity. Recently the mechanism of bronchial asthma has been researched from cellular level, molecular level gene, and found that the morbility of bronehial asthma has been related with some inununologie cell, some eytokine,lots of biontexxitatory and genetic faetore. The research progress in this field was reviewed in this paper,ineluding the mechanism of ammunology, neuromeehanism, heredity factor.