|
|||||
|
|
Hypomelanosis of Ito and precocious puberty |
|
| Authors: | P. E. F. Daubeney K. Pal R. Stanhope |
| Affiliation: | (1) The Hospitals for Sick Children, Great Ormond Street, WC1N 3JH London, UK;(2) Guy's Hospital, St. Thomas' Street, SE1 9RT London, UK;(3) The Medical Unit, Institute of Child Health, 30 Guilford Street, WC1N 1EH London, UK |
| Abstract: | We describe two girls with hypomelanosis of Ito, one of whom was demonstrated to have diploid-triploid mixoploidy in skin fibroblasts. Both had precocious puberty which was probably gonadotrophin-independent. The association of precocious puberty and hypomelanosis of Ito has not been previously reported. We have speculated on the possible mechanism of gonadotrophin-independent precocious puberty. |
| Keywords: | Hypomelanosis of Ito Precocious puberty Gonadotrophin-independence |
| 本文献已被 SpringerLink 等数据库收录！ | |