The effect of p-bromomethamphetamine (V-111), a selective serotoninergic amphetamine, on the convulsive seizure excitability threshold in mice

The effect of p-bromomethamphetamine (V-111), a selective serotoninergic amphetamine analogue, on convulsive seizure excitability threshold was evaluated in male albino mice. It was found to be most effective in subcutaneous doses of 15 mg/kg and intracerebroventricular doses of 25 fig per mouse. In a single dose of 15mg/kg, V-111 elevated the pentylenetetrazol threshold when the latter was applied at 30 min, 1 hr or 3 hr; after this time V-111 decreased the threshold. The effect of V-111 on the pentylenetetrazol threshold was changed by drugs which influence serotoninergic synaptic transmission.

p-Chlorophenylalanine decreased the threshold while 5-hydroxytryptophan, imipramine and the combination of 5-hydroxytryptophan and imipramine increased it. Nialamide caused no change in the threshold. The changes in the convulsive seizure excitability threshold are considered to be due to inhibition of intraneuronal 5-hydroxytryptamine and dopamine uptake and alteration of the brain level of 5-hydroxytryptamine induced by V-111.