心肌梗死心脏破裂患者血浆C反应蛋白和D-二聚体水平的变化

目的:探讨测定血浆C反应蛋白(CRP)和D-二聚体水平在冠心病急性心肌梗死(AMI)心脏破裂患者中的临床意义。方法:观察50例AMI心脏破裂(心室游离壁破裂)患者血浆CRP和D-二聚体水平,并与50例AMI但未发生心脏破裂的患者进行对照比较。结果:心脏破裂患者组(实验组)CRP和D-二聚体水平较未破裂组(对照组)明显升高,CRP和D-二聚体水平高低与心脏破裂的发生率呈正相关(P<0.05)。从风险比看,高CRP患者的破裂风险是低的4.125倍,高D-二聚体患者的破裂风险是低的2.471倍。结论:AMI患者的血浆CRP和D-二聚体水平,作为一种敏感性指标,对预测心肌梗死患者发生心脏破裂有一定的价值。

Changes of serum levels of C-reactive protein and D-dimer in patients with cardiac rupture after myocardial infarction

Objective:To investigate the clinical significance of detecting C-reactive protein(CRP) and D-dimer in patients with cardiac rupture after acute myocardial infarction(AMI).Methods:Serum levels of CRP and D-dimer were observed in 50 patients with cardiac rupture after AMI,and compared with those of 50 AMI patients without cardiac rupture.Results:Serum levels of CRP and D-dimer were significantly elevated in patients with cardiac rupture(experimental group) than those without cardiac ruptured(control group).Serum levels of CRP and D-dimer were positively related with the incidence of cardiac rupture(P<0.05).The risk of cardiac rupture in patients with high CRP was 4.125 times than those with low CRP,and high D-dimer was 2.471 times than those with low D-dimer level.Conclusions:As a sensitive index,serum levels of CRP and D-dimer may predict the incidence of the cardiac rupture in patients with AMI.