口腔癌引流区淋巴结反应性增生与微转移关系的研究

目的：明确口腔癌引流区淋巴结反应性增生与微转移之间的联系。方法：收集四川大学华西口腔医院住院治疗的12例口腔鳞癌患者术后颈部淋巴结标本共233个，通过病理检测分为正常、反应性增生和转移3组，采用免疫组化检测前2组微转移，结果使用SPSS10．0进行统计学分析。结果：25个淋巴结病理检查为转移，79个反应性增生，129个正常；正常黏膜上皮、鳞状细胞癌与转移淋巴结呈角蛋白强阳性，反应性增生与正常淋巴结的微转移检出率分别为29／79、12／129。结论：癌引流区反应性增生的淋巴结较正常淋巴结更易出现微转移。

A study on the relationship between reactive hyperplasia of the draining lymph nodes and oral cancer micrometastasis

Objective:To investigate the relationship between reactive hyperplasia of the draining lymph nodes and oral cancer micrometastasis.Methods:The specimens was taken from 12 patients suffered from oral squamous cell carcinoma,who accepted inpatient care in West China College of Stomatology,Sichuan University.There were totally 233 lymph nodes,and all the specimens were divided into normal,reactive hyperplasia and metastasis groups by pathological diagnosis.Immunohistochemistry method was used to inspect micrometastasis in the two prior groups,and the data were analyzed with SPSS 10.0.Results:25 lymph nodes were detected metastasis,79 were reactive hyperplasia,and 129 were normal.Normal mucosa,squamous cell carcinoma and metastatic lymph nodes were positive to keratin,and there were 29 and 12 specimens with micrometastasis in reactive hyperplasia and normal lymph nodes separately.Conclusion:Micrometastasis occured on the reactive hyperplasia lymph node in the oral cancer draining area is easier than that on the normal one.