| 支气管哮喘与免疫调节 |
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| 引用本文： | 李艳,戚好文. 支气管哮喘与免疫调节[J]. 国际呼吸杂志, 2008, 28(7): 400-402 |
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| 作者姓名： | 李艳 戚好文 |
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| 作者单位： | 第四军医大学附属西京医院呼吸内科,西安,710000 |
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| 摘 要： | 支气管哮喘(哮喘)是由环境过敏原引起基因易感人群Th1/Th2免疫失衡,Th2功能亢进而引起的.产生Th2细胞因子的CD4+T细胞在哮喘发生过程中起了关键的作用[1].各种特异性致炎因子,调节性T细胞,抗原呈递细胞以及免疫球蛋白(Ig)都参与了哮喘的发生,本文就哮喘与免疫调节的关系以及免疫治疗的前景作一综述.
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| 关 键 词： | 哮喘 免疫调节 调节性T细胞 免疫球蛋白E |
Bronchial asthma and immunomodulation |
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| LI Yan,QI Hao-wen. Bronchial asthma and immunomodulation[J]. International Journal of Respiration, 2008, 28(7): 400-402 |
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| Authors: | LI Yan QI Hao-wen |
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| Abstract: | Asthma is caused by dysregulated Th2-biased immune responses to environmental allergens in genetically predisposed individuals.Asthma is characterized by cytokine pathology.CD4+ T cells that produce Th2 cytokines play a prominent role in the lungs of asthmatic subj ects.In addition,there are many other agents such as proinflammatory factor,antigen presenting cell and immunoglobulin E which all play important roles in the pathogeness of asthma. This text makes a review of the relation between asthma and immunomodulation,and the perspective of the immunotherapy. |
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| Keywords: | Asthma Immunomodulation Regulatory T cells Immunoglobulin E |
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