The use of a computer in ventilation-perfusion scintigraphy with Tc-99m macroaggregates and Kr-81m,to obtain a physiological model

In this article we describe a computer program to demonstrate ventilation-perfusion relationships in the lungs, using ^99mTc-MAA and ^81mKr, with the patients sitting upright, the normal physiological situation. The ventilation and perfusion scans are performed simultaneously with both gamma camera and computer adjusted for dual isotope mode. Steady state images are acquired in frontal, dorsal, and left and right posterior oblique positions. Additionally, in the dorsal and frontal projections, a sequence of 12 washout images (5 s) is registered, after closing the Krypton supply. After normalization and further computer processing, the following parameters are calculated in the frontal and dorsal projections, in the whole lung and in four horizontal subregions: washout values, ventilation-perfusion ratios, left to right ratios of ventilation and perfusion, and left to right ratios of the everage pixel values for ventilation and perfusion. Results in a group of eight healthy volunteers are described and discussed.