韶关市1190例手足口病病原体检测结果分析

目的分析韶关地区手足口病病原体分布情况。方法收集2011年1月～12月的1190例手足口病患者的咽拭子，采用实时荧光PCR方法检测肠道病毒71型（EV71）和柯萨奇病毒A组16型（CoxAl6）。结果在1190份标本中病毒核酸阳性率为11．51％（137／1190），其中Ev71占60．58％（83／137），CoxAl6占39．42％（54／137）；6月份高发，占29．08％（346／1190）；男女比例为1．64：1，且0～4岁的患儿占93．11％。结论韶关地区2011年手足口病病原体以Ev71为主，6月份高发，主要分布在0-4岁，男性多于女性，实时荧光PCR可用于手足口病病原体的检测，对手足口病的诊疗和防控具有重兽膏义。

Analysis and pathogenic diagnosis of 1190 hand-foot-mouth disease in Shaoguan

Objective To analyze the pathogenic diagnosis of the hand-foot-mouth disease （HFMD） in the city of Shaoguan. Methods Throat swab of 1190 HFMD patients were collected from January to December in 2011. Real-time PCR was used to detect enterovirus71 （EV71） and CoxsackievirusAl6 （CoxA 16）. Results The positive rate of the virus nucleic acid was 11.51%（137/1190）, EV71 was 60.58%（83/137） , CoxA16 was 39.42%（54/137）. The peak of HFMD infection ratio was 29.08% （346/1190） in June. Male to female ratio was 1.64：1, 0-4 years old children accounted for 93.11%. Conclusions HFMD was mainly caused by EV7I in Shaoguan 2011. The peak of HFMD was in June and mainly distributed in 0-4 years old children. Male more than female. Real-time PCR can be used to pathogenic diagnosis of HFMD, which plays an important role in diagnosis, treatment, prevention and control of HFMD.