国产和进口rHuEPO治疗长期血透慢性肾衰竭贫血患者的疗效比较

研究和比较国产与进口基因重组人红细胞生成素（ｒＨｕＥＰＯ）对长期血液透析（ＨＤ）慢性肾衰竭（ＣＲＦ）贫血患者的影响。将６０例长期血透慢性肾衰竭贫血病人随机分成２组，分别应用国产ｒＨｕＥＰＯ（益比奥）、进口ｒＨｕＥＰＯ（生血素）１００μｇ／（ｋｇ·周），均分３次治疗。２组患者在治疗第２周网织红细胞（ＲＲＢＣ）均显著上升，治疗１２周内血细胞比容（ＨＣＴ）均达到０．３０以上，且生活质量均有所改善。表明国产、进口ｒＨｕＥＰＯ疗效无显著性差异，均可安全、有效地改善ＣＲＦ患者贫血状态。

Comparison of the Effect of Homemade rHuEPO and Imported rHuEPO on Treating Patients with Anemia in Chronic Renal Failure Udergoing Long-term Hemodialysis

To study and compare the effect of homemade recombinant human erythropoietin(rHuEPO) with that of imported rHuEPO on patients with anemia in chronic renal failure(CRF) undergoing longterm maintenance hemodialysis. Sixty patients with anemia in CRF undergoing longterm hemodialysis in our hospital were divided into two groups at random. The two groups were treated with homemade and imported rHuEPO respectively. The rate of retculocyte of the patients in both groups increased significantly after a week. HCT reached above thirty percent within twelve weeks and the quality of living was also improved after treatment. There are some side effects such as hypertension, headache, hyperkalemia et al in both group. Either homemade or imported rHuEPO could improve the anemia in CRF safely and effectively. There is no significant difference in the effect of treatment between the two groups.