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| 凋亡相关基因Bcl-2、Bax在胎儿宫内发育受限胎盘组织中表达的探讨 | |
| 引用本文： | 杨鹃,王豫黔,赵轩,邓飞,丛棣. 凋亡相关基因Bcl-2、Bax在胎儿宫内发育受限胎盘组织中表达的探讨[J]. 贵州医药, 2002, 26(9): 777-778 |
| 作者姓名： | 杨鹃 王豫黔 赵轩 邓飞 丛棣 |
| 作者单位： | 1. 大连市妇产医院,116012 2. 遵义医学院附属医院,563003 3. 大连市第四人民医院,116031 |
| 基金项目： | 贵州省卫生厅科研基金资助项目 (No .2 0 0 0 D12 6) |
| 摘 要： | 目的：探讨在胎儿宫内发育受限（FGR）胎盘组织中凋亡相关基因Bcl-2、Bax表达的关系。方法：免疫组化SP法检测足月正常体重儿（对照组）25例和FGR组20例胎盘组织中Bcl-2、Bax的表达。图像分析系统进行单个绒毛中阳性细胞率、总面积、平均吸光度（A）测定，量化Bcl-2、Bax蛋白。结果：与对照组比较，FGR组胎盘组织中Bcl-2阳性细胞率及单个绒毛阳性细胞面积占总面积百分比均明显减少，A值增高（P均＜0．01）；而Bax阳性细胞率、面积比均明显增加，A值降低（P均＜0．01）。结论：FGR组胎盘组织中促凋亡基因Bcl-2表达下降，抑凋亡基因Bax表达增高。 |
| 关 键 词： | 胎儿发育受限 胎盘 基因Bcl－2 基因Bax |
Expression of Bcl-2 and Bax gene of fetal growth retardation in placenta |
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| Yang Juan,Wang Yuqian,Zhao Xuan,et al.. Expression of Bcl-2 and Bax gene of fetal growth retardation in placenta[J]. Guizhou Medical Journal, 2002, 26(9): 777-778 | |
| Authors: | Yang Juan Wang Yuqian Zhao Xuan et al. |
| Affiliation: | Yang Juan,Wang Yuqian,Zhao Xuan,et al.Department of Obsterics and Gynecology,Affiliated Hospital of Zunyi medical College,Zunyi 563003 |
| Abstract: | objective To evaluate Bcl 2 and Bax gene expression of Fetal growth retardation(FGR) in placenta. Methods The expression of Bcl 2 and Bax were detected by streptavidin peroxidase techniques in placenta of 25 normal pregnancy women and 20 cases with FGR. Positive cells rate and the ratio of positive area in single villi and absorbance(A) were measured by image analysis system. Results Compared with the control, Bcl 2 positive cells rate and the area ratio of positive to villi both decreased significantly in placenta of FGR, in which A increased significantly ( P <0.01). However, the Bax results were opposite ( P <0.01).Conclusion There are lower expression of Bcl 2 and higher expression of Bax in placenta of FGR. |
| Keywords: | Fetal growth retardation Placenta Gene Bcl 2 Gene Bax |
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