脑脉通冻干粉针剂改善脑缺血性麻醉犬脑循环的初步实验结果

目的：观察脑脉通冻干粉针剂对脑缺血性麻醉犬脑循环的影响。方法：将麻醉犬随机分为脑脉通高（4 mg/kg）、中（2 mg/kg）、低（1 mg/kg）剂量组,尼莫地平（0.2 mg/kg）组及阴性对照组（生理盐水）,每组6只。记录给药前及给药后5、10、15、30、60、90、120分钟脑血流量、血压和心率变化。结果：与给药前比较,脑脉通高剂量组麻醉犬在药后5分钟时,脑血管阻力开始降低（P〈0.05）,30分钟时,降幅达到最大值（P〈0.01）;脑血流量的增加亦出现在药后5分钟（P〈0.05）,30分钟时达到最高值（P〈0.01）。中剂量组麻醉犬在药后15和30分钟时,脑血管阻力明显降低;药后10、15、30、60分钟时的脑血流量均比用药前有明显增加（P〈0.05,P〈0.01）。但与阴性对照组相比并无明显差异。本品对麻醉犬的血压和心率无明显影响。结论：适当剂量的脑脉通冻干粉针剂对脑循环可能有改善作用。

An Initial Result on Improving Effect of Nao-Mai-Tong Freeze-dried Powder Injection on Cerebral Circulation in Anesthetic Cerebral Ischemia Dogs

Objective： To observe the improving effect of Nao-Mai-Tong Freeze-dried Powder Injection （NFP） on the cerebral circulation in anesthetic cerebral isehemia dogs. Methods： The anesthetized dogs were randomly divided into five groups with 6 dogs in each group： ① control group, ② Nimodipine （ 0.2 mg/kg） group, ③the high dose NFP （4 mg/kg） group, ④the medium dose NFP （2 mg/kg） group and ⑤the low dose NFP（ 1 mg/kg） group. The changes of cerebral blood flow（CBF）, cerebral vascular resistance （CVR）, mean arterial pressure （MAP） and heart rate （HR） were determined before and 5, 10, 15, 30, 60, 90, 120 min after administrated the test drugs by intravenous drip. Results： At 5 rain after giving the drug, CBF increased and CVR decreased in high dose NFP group, with obvious differences from those before giving the drug （P 〈0.05） and the maximum change values were at 30 min（P 〈0.01）. In the medium dose NFP group, CVR decreased and CBF increased at 15 and 30 min after giving the drug with obvious differences from those before giving the drug （ P 〈 0. 05, P 〈 0. 01 ） but without obvious differences from those of control group. Morever, MAP and HR in three NFP groups had no significant change before and after giving the drug. Conclusion： NFP at a suitable dosage may improve the cerebral circulation.