| 中国慢性乙型肝炎病毒感染者病毒基因型及基因亚型分布 |
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| 引用本文： | 孙奎霞,李杰,闫玲,孙秘书,马俊凤,陈杰,聂晶晶,庄辉. 中国慢性乙型肝炎病毒感染者病毒基因型及基因亚型分布[J]. 中国自然医学杂志, 2011, 0(3) |
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| 作者姓名： | 孙奎霞 李杰 闫玲 孙秘书 马俊凤 陈杰 聂晶晶 庄辉 |
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| 作者单位： | 北京大学医学部病原生物学系; |
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| 基金项目： | 国家“十一五”艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2008ZX10002-001) |
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| 摘 要： | 目的了解中国不同地区慢性乙型肝炎病毒(HBV)感染者中HBV基因型及基因亚型分布特点。方法从我国东部(山东、江苏)、西部(新疆)、南部(广东、广西)、北部(吉林、北京)及中部(河南、河北)5个地区的9个省、自治区、直辖市收集735份慢性HBV感染者血清样品,用本实验室建立的型特异性引物巢式聚合酶链反应法(nPCR)检测HBV基因型及基因亚型。结果 735份样品中,71.8%(528/735)为C型,10.3%(76/735)为B型,6.3%(46/735)为D型,11.6%(85/735)为混合型,未检测到其他基因型。528份C型样品中,C2亚型占94.0%(496/528),C1亚型占4.9%(26/528),C1+C2混合亚型占1.1%(6/528);76份B型样品中,B2亚型占90.8%(69/76),B1亚型占5.3%(4/76),B1+B2混合亚型占3.9%(3/76)。除西部新疆地区C型相对较少(31/116,26.7%)外,其他地区均以C型为主。D型主要分布在西部新疆地区,占31.9%(37/116)。混合型在各地区均有发现,但以西部和南部地区相对多见,分别占30.2%(35/116)和20.0...
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| 关 键 词： | 乙型肝炎病毒 基因型 基因亚型 分布特点 |
Distribution of hepatitis B virus genotypes and subgenotypes in Chinese patients with chronic hepatitis B virus infection |
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| SUN Kui-xia,LI Jie,YAN Ling,SUN Mi-shu,MA Jun-feng,CHEN Jie,NIE Jing-jing,ZHUANG Hui. Distribution of hepatitis B virus genotypes and subgenotypes in Chinese patients with chronic hepatitis B virus infection[J]. Chinese Journal of Natural Medicine, 2011, 0(3) |
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| Authors: | SUN Kui-xia LI Jie YAN Ling SUN Mi-shu MA Jun-feng CHEN Jie NIE Jing-jing ZHUANG Hui |
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| Affiliation: | SUN Kui-xia,LI Jie,YAN Ling,SUN Mi-shu,MA Jun-feng,CHEN Jie,NIE Jing-jing,ZHUANG Hui Department of Microbiology,Peking University Health Science Center,Beijing 100191,China |
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| Abstract: | Objective To investigate the characteristics of the genotypes and subgenotypes distribution of hepatitis B virus(HBV) among chronic hepatitis B patients in the different areas of China.Methods A total of 735 serum samples of chronic hepatitis B patients were collected from nine provinces,which were located in the eastern(Shandong and Jiangsu),western(Xinjiang autonomous region),southern(Guangdong and Guangxi),northern(Jilin and Beijing),and central(Henan and Hebei) areas of China,respectively.HBV infection ... |
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| Keywords: | Hepatitis B virus Genotype Subgenotype Distribution |
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