| p27基因和蛋白表达的调控及其在肿瘤发生机制中的作用 |
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| 引用本文： | 张欣,张志刚.p27基因和蛋白表达的调控及其在肿瘤发生机制中的作用[J].国际病理科学与临床杂志,2009,29(2):170-174. |
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| 作者姓名： | 张欣 张志刚 |
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| 作者单位： | 复旦大学上海医学院病理系,上海,200032 |
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| 摘 要： | p27-kip1基因编码的P27蛋白作为细胞周期蛋白依赖性激酶抑制剂，在细胞周期进程中起重要的负调节作用，同时作为一个新的肿瘤抑制基因，与肿瘤的发生、发展及预后密切相关，近年来调节P27机制的新发现为肿瘤治疗开辟了新的道路。
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| 关 键 词： | p27 细胞周期 肿瘤 |
| 收稿时间： | 2008-10-15 |
| 修稿时间： | 2009-3-24 |
Regulation of p27 gene expression and its role in tumor generation |
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| ZHANG Xin,ZHANG Zhigang.Regulation of p27 gene expression and its role in tumor generation[J].Journal of International Pathology and Clinical Medicine,2009,29(2):170-174. |
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| Authors: | ZHANG Xin ZHANG Zhigang |
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| Institution: | Department of Pathology, Shanghai Medical College, Fudan University, Shanghai 200032, China |
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| Abstract: | As an inhibitor of cyclin-dependent kinase, P27 protein encoded by p27-kip1 gene plays an important role of negative regulation in cell cycle process. At the same time, as a new candidate of tumor suppressor gene, it is closely related to tumor’s occurrence, development and prognosis. In recent years, new discoveries of the regulative mechanism of p27 open a new way in the tumor treatment. |
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| Keywords: | p27 |
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