| 血管内皮生长因子:从血管形成到神经元保护 |
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| 引用本文： | 顾卫东,薛庆生,于布为.血管内皮生长因子:从血管形成到神经元保护[J].国际麻醉学与复苏杂志,2006,27(6):354-356. |
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| 作者姓名： | 顾卫东 薛庆生 于布为 |
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| 作者单位： | 1. 上海交通大学医学院瑞金医院麻醉科,200025;上海瑞金医院集团闵行医院麻醉科,200025
2. 上海交通大学医学院瑞金医院麻醉科,200025 |
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| 基金项目： | 上海交通大学医学院博士学科点建设基金资助项目（项目编号：BXJ0612）. |
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| 摘 要： | 血管内皮生长因子(vascular endotjelial growthfactor,VEGF)是一类多功能的生长因子。它具有促进内皮细胞增殖、诱导血管形成的作用,因而被应用于缺血性血管疾病(如缺血性心肌病和下肢缺血)的治疗,并成为近年来心血管病研究的热点之一。新近研究发现,VEGF及其受体在中枢神经组
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| 关 键 词： | 血管内皮生长因子 神经元保护作用 血管形成 缺血性血管疾病 内皮细胞增殖 缺血性心肌病 中枢神经组织 VEGF |
Vascular endothelial growth factor: from angiogenesis to neuroprotection |
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| GU Wei-dong,XUE Qing-sheng,YU Bu-wei.Vascular endothelial growth factor: from angiogenesis to neuroprotection[J].international journal of anesthesiology and resuscitation,2006,27(6):354-356. |
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| Authors: | GU Wei-dong XUE Qing-sheng YU Bu-wei |
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| Institution: | Department of Anesthesiology, Ruijin Hospital, Shanghai 200025, China |
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| Abstract: | Vascular endothelial growth factor(VEGF),a highly conserved heparin-binding protein,was found originally in vascular endothelial cells and showed a high potency for angiogenesis and endothelial proliferation.VEGF can induce collateral growth in the ischemic tissue and therefore,is used in the treatment of ischemic vascular disease.Recently,Endogenous expression of VEGF mRNA and VEGF has been observed in neuronal cells,and its expression is up-regulated by ischemia-reperfusion.Besides its role on angiogenesis,recent evidence indicates that VEGF can also act directly on neurons to produce neurotrophic and neuroprotective effects. |
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| Keywords: | vascular endothelial growth factor angiogenesis neuroprotection |
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