Recognition of viral antigens in 6/94 virus-induced T-cell-mediated cytotoxicity |
| |
Authors: | Karin Pickel Maxine J. Solvay |
| |
Affiliation: | (1) Institute of Virology and Immunobiology, University of Würzburg, Versbacher Landstrasse 7, D-8700 Würzburg, Federal Republic of Germany |
| |
Abstract: | Distinct events in the virus-stimulated T-cell-mediated cytotoxicity (V-CMC) have been investigated: 1.) The induction of V-CMC is possible by immunizing mice with infectious as well as UV-inactivated virus (parainfluenza type 1 strain 6/94), or with virus-infected cells either compatible or imcompatible with the recipient. 2.) Recognition of viral antigens by the effector cells occurs independently of the H2 environment: Fractionation of effector cells on columns loaded with virus-infected cells eliminates virus-specific cytotoxic cells. Effector cells and cells on the column need not share H-2 antigens. The findings are discussed with regard to the H2 restriction of the virus induced T-cell mediated cytotoxicity.This paper was presented at the Sixteenth Symposium of the European Association Against Virus Diseases in Amsterdam, September 7–9, 1977 |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|