医院内感染菌群变化趋势及耐药性分析

目的了解医院内感染病原菌群及其耐药性变化的趋势。方法对各病区5年中院内感染病原菌的分离及对抗生素的耐药情况进行统计分析。结果统计结果表明,列前10位的院内感染病原菌依次为:铜绿假单胞菌(21.5％)、酵母菌(16.2％)、大肠埃希菌(11.9％)、不动杆菌(9.9％)、肠球菌(8.9％)、肺炎克雷伯菌(8.6％)、阴沟肠杆菌(6.1％)、金黄色葡萄球菌(4.4％)、嗜麦芽窄食单胞菌(3.4％)、粘质沙雷菌(1.6％)。亚胺培南对铜绿假单胞菌的耐药率由15％升高至24％。哌拉西林/他唑巴坦、头孢哌酮/舒巴坦对G~-细菌的耐药率也呈逐年上升的趋势;耐万古霉素的肠球菌在逐年增加自,0～5％;结论 5年中,我院G~-、G~+细菌及酵母菌的分离率变化不大,细菌耐药性普遍提高。

Analysis on changes of infectious bacteria flora in hospital and drug resistance

Objective To understand the nosocomial infected pathogens and the change of the resistance to some antibiot- ics. Methods Statistical methods was used to analysis the isolation rate of nosocomial infected pathogens and the resistance to some antibiotics in the last five years. Results Among pathogens P. aeruginosa (21.5%) was still the first one in nosocomial infection, after it were Yeast (16.2%), E. coli (11.9%), Acinetobacter spp (9.9%), Enterococcus spp (8.9%), K. pneumoniae (8.6%). E. cloacae (6.1%), S. aureus (4.4%), S. maltophilia (3.4%) and S. marcescens (1.6%). The resistance rate of lmipenem to P. aeruginosa raised from 15% to 24%. The resistant rate of Piperacillin/Tazobactam and Cefoperazone/Sulbactam to some gram neg- ative strains also raised. The strains of VREs raised from 0 to 5%. Conclusions In The five years, the isolation rate of gram negative strains. gram positive strains and Yeast changed not greatly. but the resistant rate raised heavily.