Effects of a new thyrotropin-releasing hormone analogue (DN-1417) on evoked responses and long-term potentiation in the dentate gyrus of rat |
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| Authors: | K Morimoto G V Goddard N E Sirett |
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| Affiliation: | 1. Research Department, Neuropsychopharmacology Unit, Albacete General Hospital, 37 Hermanos Falcó Street, Albacete E-02006, Spain;2. Department of Genetics, Faculty of Medicine, University of Castilla-La Mancha, 14 Almansa Street, Albacete E-02006, Spain;3. INCYL, University of Salamanca, 1 Pintor Gallego Street, Salamanca E-37007, Spain |
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| Abstract: | The effects of a recently synthesized analogue, thyrotropin-releasing hormone (TRH) analogue, DN-1417, on evoked responses and long-term potentiation (LTP) of the perforant path input to the dentate gyrus were examined in normal rats and after hypophysectomy. Eighty micrograms of DN-1417 injected i.c.v. reduced granule cell excitability with a small increase in the excitatory postsynaptic potential (EPSP) and reduced LTP of the EPSP. However, DN-1417 slightly increased the potentiation of the population spike. Similar results were obtained in a rat 7 days post-hypophysectomy. It is concluded that the effects of DN-1417 on LTP are similar to those of TRH and may be unrelated to its endocrine actions. |
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