| 乳腺癌患者血清可溶性肿瘤标志物的临床价值研究 |
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| 引用本文： | 赵晶,刘红,张爱敏,顾林.乳腺癌患者血清可溶性肿瘤标志物的临床价值研究[J].中国肿瘤临床,2008,35(24):1411-1414. |
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| 作者姓名： | 赵晶 刘红 张爱敏 顾林 |
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| 作者单位： | 1. 乳腺痛防治教育部重点实验室,天津市肿瘤防治重点实验室,天津医科大学附属肿瘤医院乳腺科,天津市,300060
2. 乳腺痛防治教育部重点实验室,天津市肿瘤防治重点实验室,天津医科大学附属肿瘤医院检验科,天津市,300060 |
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| 摘 要： | 目的:探讨血清可溶性肿瘤标志物CEA、CA-153、ICAM-1、E-selection单项及联合检测在乳腺癌中的诊断价值.方法:选取不同临床分期乳腺癌患者130例.乳腺良性肿瘤患者30例,正常人群30例.通过酶联免疫吸附法(ELISA)测定各项指标血清浓度并进行比较.结果:乳腺癌CEA、CA-153、ICAM-1、E-selection血清浓度均显著高于良性肿瘤组及正常人群(P<0.01),且其血清浓度与肿瘤分期密切相关.在疾病进展的转移性乳腺癌中,各指标出现明显升高(P<0.01).CEA、CA-153、ICAM-1、E-selection单项检测对于乳腺癌的诊断敏感性较低.多指标联合检测可不同程度提高检测的敏感性,以含CA-153及E-selection组合最为显著.结论:E-selection、ICAM-1、CEA、CA-153均为乳腺癌重要的血清标志物,在肿瘤的发生、发展及转移过程中发挥重要的作用.对恶性肿瘤患者的多指标联合检测可在不显著降低特异性的基础上提高诊断的敏感性,为判断预后及监测病情提供重要价值.
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| 关 键 词： | 乳腺癌 肿瘤标志物 |
The Significance of Detecting Serum Soluble Tumor Markers for Patients with Breast Cancer |
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| ZHAO ding,LIU Hong,ZHANG Aimin,Gu Lin.The Significance of Detecting Serum Soluble Tumor Markers for Patients with Breast Cancer[J].Chinese Journal of Clinical Oncology,2008,35(24):1411-1414. |
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| Authors: | ZHAO ding LIU Hong ZHANG Aimin Gu Lin |
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| Institution: | ZHAO Jing,LIU Hong,ZHANG Aimin,Gu Lin Department of Breast Cancer,Cancer Institute , Hospital of Tianjin Medical University,Tianjin 300060,China |
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| Abstract: | Objective:To investigate the clinical value of detecting serum levels of CEA,CA-153,ICAM-1,and E-se-lectin for patients with breast carcinoma.Methods:Using chemiluminescent immunoassay,we detected the serum levels of CEA,CA-153,ICAM-1 and E-selectin in 130 patients with breast cancer,30 patients with be-nign breast tumors and 30 healthy control subjects.Results:The serum levels of CEA,CA-153,ICAM-1,and E-selectin in the breast cancer group were significantly higher than those in the benign breast disease gr... |
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| Keywords: | CEA CA-153 ICAM-1 E-selectin |
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