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苦参碱对纤维蛋白纤维蛋白原降解产物诱导血管细胞损伤、增殖及腹腔巨噬细胞释放IL-1的影响
引用本文:周斌,胡振林,张俊平,钱定华.苦参碱对纤维蛋白纤维蛋白原降解产物诱导血管细胞损伤、增殖及腹腔巨噬细胞释放IL-1的影响[J].药学学报,1999,34(5):342-344.
作者姓名:周斌  胡振林  张俊平  钱定华
作者单位:上海第二军医大学药学院药理教研室
摘    要:目的:研究苦参碱(Mat)对纤维蛋白纤维蛋白原降解产物(FFDP)作用的影响。 方法:大鼠主动脉内皮细胞损伤以乳酸脱氢酶释放测定;大鼠主动脉平滑肌细胞增殖采用结晶紫染色法测定;白细胞介素-1活性采用小鼠胸腺细胞增殖法测定。结果:FFDP能促进大鼠主动脉内皮细胞释放乳酸脱氢酶,诱导大鼠主动脉平滑肌细胞增殖,并促使小鼠腹腔巨噬细胞分泌IL-1增加。结论:Mat可抑制FFDP的作用。对动脉粥样硬化的防治可能有一定意义。

关 键 词:纤维蛋白纤维蛋白原降解产物(FFDP)  苦参碱  白细胞介素-1(IL-1)  平滑肌细胞  内皮细胞  腹腔巨噬细胞
收稿时间:1998-08-03

EFFECTS OF MATRINE ON THE INJURY AND PROLIFERATION OF VASCULAR CELLS AND RELEASE OF INTERLEUKIN-1 ROM PERITONEAL MACROPHAGES CAUSED BY FIBRIN FIBRINOGEN DEGRADATION PRODUCTS
Zhou Bin,Hu Zhenlin,Zhang Junping and Qian Dinghua.EFFECTS OF MATRINE ON THE INJURY AND PROLIFERATION OF VASCULAR CELLS AND RELEASE OF INTERLEUKIN-1 ROM PERITONEAL MACROPHAGES CAUSED BY FIBRIN FIBRINOGEN DEGRADATION PRODUCTS[J].Acta Pharmaceutica Sinica,1999,34(5):342-344.
Authors:Zhou Bin  Hu Zhenlin  Zhang Junping and Qian Dinghua
Abstract:AIM: To study the effects of matrine on rat aortic endothelial cell injury, rat aortic smooth cell proliferation and release of interleukin-1 from mouse peritoneal macrophages induced by fibrin fibrinogen degradation products(FFDP). METHODS: Rat aortic endothelial cell injury was assayed by lactic dehydrogenase release. Rat aortic smooth muscle cell proliferation was determined by crystal violet staining assay. Interleukin-1 activity was measured by mouse thymocyte proliferation assay. RESULTS: Fibrin fibrinogen degradation products significantly increased the lactic dehydrogenase release from rat aortic endothelial cells, proliferation of rat aortic smooth muscle cells and release of interleukin-1 from mouse peritoneal macrophages. Matrine exerted inhibitory effects on the action of fibrin fibrinogen degradation products. CONCLUSION: Fibrin fibrinogen degradation products may play an important role in atherosclerosis plaque formation, and matrine has protective effects against the atherosclerotic injury.
Keywords:matrine  interleukin-1  endothelial cell  smooth muscle cell  peritoneal macrophage  fibrin fibrinogen degradation products
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